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Abbreviations ADIPOQ: Adiponectin ADRP: Adipose differentiation-related protein ADSC: Adipose tissue derived Stem Cells ALP: Alkaline phosphatase AMPK: AMP-activated protein kinase ANG-1: Angiopoietin-1 APN: Adiponectin APOM: Apolipoprotein M AP2: Activator Protein 2 ATGL: Adipose triglyceride lipase BAX: Bcl-2-associated X protein BCL-2: B-cell lymphoma 2 BMP2: Bone morphogenetic protein 2 BMSC: Bone marrow mesenchymal stem cell C/EBP: CCAAT/enhancer-binding protein alpha cAMP: Cyclic adenosine monophosphate CAV1: Caveolin-1 CCK-8: Cell Counting Kit-8 CDK: Cyclin-dependent kinase CERSS: Ceramide synthase 5 COL1: Collagen type I COL10A1: Collagen type X alpha 1 chain COL1A1: Collagen type I alpha 1 chain COL2: Collagen type II COLI: Collagen-1 DEGS1: Delta (4) -desaturase, sphingolipid 1 DKK-1: Dickkopf-1 DLK1: Delta-like 1 homolog DMEM: Dulbeccos Modified Eagle Medium DTZ: Dithizone EAT: Epicardial adipose tissue EdU: 5-ethynyl-2-deoxyuridin EGF: Endothelial-growth factor EPC: Endothelial progenitor cells ERK: Extracellular signal-regulated kinase Ex-4: Exendin-4 FABP4: Fatty acid-binding protein 4 FASN: Fatty acid synthase FBS: Fetal bovine serum FOXO1: Forkhead box protein O1 GIP: Gastric inhibitory polypeptide GIP-R: Gastric inhibitory peptide receptor GIP-RA: Gastric inhibitory polypeptide receptor agonist GLP-1: Glucagon-like peptide-1 GLP-1-R: Glucagon-like peptide-1 receptor GLP-1-RA: Glucagon-like-peptide-1 receptor agonist GLUT1: Glucose transporter type 1 GLUT2: Glucose transporter type 2 GLUT4: Glucose transporter type 4 GSK-3: Glycogensynthase-kinase 3 beta hASC: human adipose-derived stem cells hDPSC: Human dental pulp stem cells HGF: Hepatocyte-growth factor hMSC: Human mesenchymal stem cells HMSC-E4: HMSC that overexpress Ex-4 HSL: Hormone-sensitive lipase IBMX: 3-Isobutyl-1-methylxanthine IGFBP2: Insulin-like growth factor-binding protein 2 IL-10: Interleukin 10 IL1B: Interleukin 1 beta IL6: Interleukin 6 INGA-PP: Islet Neogenesis-associated protein pentadecapeptide INSR: Insulin receptor IPC: Insulin-producing cells ISL-1: ISL LIM homeobox 1 JNK: c-Jun N-terminal kinase KGF: Keratinocyte growth factor LD: Lipid droplets LiCl: Lithium chloride LINC000968: Long intergenic non-coding RNA 968 LPL: Lipoprotein lipase LPS: Lipopolysaccharides MAFA: V-maf musculoaponeurotic fibrosarcoma oncogene homolog A MAPK: Mitogen-activated protein kinase MCP1: Monocyte chemoattractant protein-1 miRNA: MicroRNA MMP9: Matrix-Metalloproteinase 9 MTS: 3-(4,5-Dimethylthiazol-2-yl) -5-(3-carboxymethoxyphenyl) -2-(4-sulfophenyl) -2 H-tetrazolium MTT: 3-(4,5-di methylthiazol-2-yl) -2,5-diphenyltetrazolium bromide NFkB: Nuclear factor kappa-light-chain-enhancer of activated B cells NGN3: Neurogenin-3 Nkx2.2: NK2 homeobox 2 OCN: Osteocalcin OSX: Osterix (SP7 transcription factor) PAX4: Paired box gene 4 PCNA: Proliferating cell nuclear antigen PDLSC: Periodontal ligament stem cells PDX-1: Pancreatic and duodenal homeobox 1 PGC1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PLIN1: Perilipin 1 PPAR: Peroxisome proliferator-activated receptor gamma pref-1: Pre-adipocyte factor-1 QUIN: Quality Assessment Tool For In Vitro Studies RAGE: Receptor for advanced glycation end products RUNX2: Runt-related transcription factor 2 s-GAG: sulfated glycosaminoglycans SAT: Subcutaneous adipose tissue SDF-1: Stromal cell-derived factor 1 SIRT1: Sirtuin 1 SOX2: SRY-box transcription factor 2 SPC: Surfactant protein C sPLA2: Secretory phospholipase A SREBP1: Sterol regulatory element-binding protein 1 SVF: Stromal vascular fraction T2D: type 2 diabetes TNF- : Tumor necrosis factor alpha TSG-6: Tumor necrosis factor-stimulated gene 6 UCP1: Uncoupling protein 1 VAT: Visceral adipose tissue VDAC3: Voltage-dependent Anion Channel 3 Wnt: Wingless/Integrated signaling pathway WNT3A: Wnt family member 3 A MEM: -Minimum Essential Medium References Holst, J

MEDI-PEEL , , ( B3), , () 50 , , , , 8809941820645 Water, Glycereth-26, Methylpropanediol, Butylene Glycol, Glycerin, 1,2-Hexanediol, Niacinamide, Neopentyl Glycol Diheptanoate, Polyglyceryl-3 Methylglucose Distearate, PEG-240/HDI Copolymer Bis-Decyltetradeceth-20 Ether, Caprylic/Capric Triglyceride, Phenyl Trimethicone, Glyceryl Stearate, Cyclopentasiloxane, PEG-60 Hydrogenated Castor Oil, Cyclohexasiloxane, Ammonium Acryloyldimethyltaurate/VP Copolymer, C12-16 Alcohols, Glutathione(990 ppm), Palmitic Acid, Hydrogenated Lecithin, Ethylhexylglycerin, Adenosine, Diospyros Kaki Fruit Extract, Chloramine T, Sodium Bicarbonate, Sodium Carbonate, Propanediol, Sodium Hyaluronate Crosspolymer (50 ppm), Prunella Vulgaris Extract, Fucus Vesiculosus Extract, Hydrolyzed Glycosaminoglycans(30 ppm), Glycine, Sodium Hyaluronate (15 ppm), Serine, Glutamic Acid, Potassium Laurate, Benzyl Glycol, Aspartic Acid, Leucine, BHT, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Threonine, Proline, Valine, Isoleucine, Hydrolyzed Hyaluronic Acid(2.5 ppm), Histidine, Methionine, Cysteine, Ectoin, Ceramide NP, Water(Carbonated Water), Panthenol, Glyceryl Glucoside, Xylitylglucoside, Anhydroxylitol, Xylitol, Hyaluronic Acid(0.05 ppm), Hydrolyzed Collagen, Polyglyceryl-10 Laurate, Polyglyceryl-10 Stearate, Raspberry Ketone, Pantolactone, Sodium Ascorbyl Phosphate, Tripeptide-1, Hexapeptide-9, Acetyl Tetrapeptide-5, Copper Tripeptide-1, Biotin, Acetyl Tetrapeptide-2, Palmitoyl Pentapeptide-4, Hexapeptide-11, Pyridoxine, Folic Acid, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Tocopherol, Cyanocobalamin, Alanine/ Histidine/ Lysine Polypeptide Copper HCl, Tripeptide-32, Linoleic Acid, Riboflavin, Beta-Carotene, Inositol, Thiamine HCl, Disodium EDTA, Fragrance

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