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TPP functions as a cofactor for several critical enzymes across three metabolic pathways: transketolase (TK) in the pentose phosphate pathway, pyruvate dehydrogenase (PDH) in glycolysis, and alpha-ketoglutarate dehydrogenase (AKD) in the Krebs cycle (6, 33, 34)

Pharmacy benefit managers (PBMs) operating in the state, including Express Scripts, CVS Caremark, and OptumRx, negotiate rebates with Novo Nordisk that affect formulary placement but do not directly reduce the price a cash-pay patient sees at the counter

95% confidence interval (CI), 0.44-0.72)

And 8% describe other severe gastrointestinal conditions

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