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1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice
Aged people whose body has been weakened through time may also suffer from wear and tear
The right dosage, combinations with other therapies, and careful monitoring are critical for success
MRI may show cerebral white matter atrophy, ventricular enlargement, periventricular gliosis, optic nerve atrophy, delayed myelin formation or dysplasia, cerebellar hypoplasia, cerebellar hemisphere atrophy, and hypersignal in the subcortical white matter [116, 117]
The further proof of the concept includes much like the skin wound healing (Seiwerth et al., 1997
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