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Immunosuppressants such as mycophenolate mofetil and azathioprine reduce disease activity but carry risks of serious infections, liver toxicity, and malignancy

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Limitations A general limitation of PET imaging is the difficulty in quantifying radiotracer binding, which usually requires drawing multiple blood samples at precise time-points to calculate the concentration of non-metabolized radiotracer in arterial plasma (arterial input function) (Laruelle, 2002