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2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain
However, the subjects in their study were too young (mean age was approximately 33.5 years), and the sample size was inadequate [258]
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