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Inclusion criteria consisted of male and female participants without child bearing ability either due to menopause, documented hysterectomy, bilateral salpingectomy, bilateral oophorectomy, or bilateral tubal ligation, as well as age of at least 18 years, a body mass index of 30, or a body mass index of 27 with the presence of hypertension or dyslipidemia [1]
Key variants tested include GIPR rs1800437, FTO rs9939609, and MC4R rs17782313each influencing appetite regulation and energy expenditure
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