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Despite this shared mechanism, the two receptors exhibit distinct expression patterns and physiological roles that are genuinely complementary: When both axes are activated concurrently, the cAMP response in pancreatic -cells exceeds that of either agonist alone, indicating synergistic rather than merely additive intracellular signaling

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Understanding the precise mechanism by which GLP-1 agonists work is essential when evaluating whether other compounds, such as berberine, share similar pharmacological properties

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