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Its effect is gradual and appears most pronounced when combined with a caloric deficit and regular physical activity

If youre in your 40s and 50s and starting to notice changes in your body your skin feels different, your sleep isnt what it used to be, your mood shifts more often, and your hair seems thinner youre likely entering perimenopause or menopause

In addition to lowering the levels of blood glucose, as shown in Figure 1 , GLP-1RAs have also been shown to have a positive effect on multiple human tissues

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Once imbalanced, it can lead to decreased bone mass, osteoporosis, and increased risk of fractures