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The starting dosage for type 2 diabetes is typically 2.5 milligrams (mg) once per week for 4 weeks, followed by a maintenance (long-term) dosage of 5 mg once per week

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This is clearly not sufficient to rescue the reward and metabolic phenotype in males, although we can hypothesize that simultaneous GLP-1R knockdown in both of these sites may produce an even more pronounced reward phenotype in males

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It remains investigational

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