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Injectable or IV forms deliver glutathione directly into the bloodstream and are typically administered under medical supervision in clinical settings
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Once internalized by the cell through the folate receptor (RFC1), MTX undergoes sequential glutamylation by folyl-polyglutamate synthase (FPGS), thus becoming MTX polyglutamates (MTX-PG 2-6 )
This is consistent with the abolition of most of the H 2 O 2 -induced glutathione oxidation in mutants for the cytosolic isoforms (Rahantaniana et al
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