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Insulin Resistance in Midlife Insulin resistance often accelerates during perimenopause
It remains an investigational medicine available only through clinical trials
Its week-long half-life (versus liraglutides 13-hour half-life) means receptors are consistently activated rather than experiencing daily fluctuation
For a non-competing adult working under physician supervision, the volume of animal evidence may justify cautious off-label use
When patients lose significant weight with GLP-1 receptor agonists, the body's centre of gravity shifts, and the biomechanical load on the spine changes
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