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By improving insulin sensitivity and reducing inflammation, GLP-1 agonists could help create a more favourable environment for hormonal therapies to work effectively
Once-weekly cagrilintide for weight management in people with overweight and obesity The Lancet (2021) 5
However, the inhibitory potency of these natural compounds remains orders of magnitude below pharmaceutical DPP-4 inhibitors
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It is important to note that both orforglipron and oral semaglutide require daily administration (compared to weekly administration for the injectable drugs), and this raises the question of ideal dosing frequency for patient convenience
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