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A 2025 structured review, analysing 13 studies across clinical trials and observational data, suggests that vitamin D supplementation of at least 2,000 IU per day for 12 weeks increased levels of a protein that supports the survival and growth of brain cells, called BDNF, by approximately 7%, while also reducing scores on validated measures of depressive symptoms[6 Trusted Source 2025 - Nutrients Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood-Cognitive Outcomes: A Structured Narrative Review ]
its dysregulation may be implicated in the pathophysiology of cancer (365)
The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP
You can make finer dose adjustments (like stepping from 0.5 mg to 0.75 mg instead of jumping straight to 1.0 mg) and you can use split dosing strategies that pre-filled pens do not allow
& Weiss, R
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