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In the STEP 2 trial, adults with obesity or overweight plus type 2 diabetes lost a mean 9.6% of their body weight at 68 weeks with semaglutide 2.4 mg vs
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And semaglutide specifically has been shown to reduce neuropathic pain in diabetic rats by inhibiting spinal neuroinflammation [8], and a 2025 review in the Korean Journal of Pain concluded that GLP-1 receptor agonists have real potential in neuropathic pain management [20]
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