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The SELECT trial, which included patients with CV disease and overweight or obesity (many also had increased risk for diabetes), showed a reduction in major adverse CV events (defined as CV death, nonfatal heart attack, and nonfatal stroke) of 20% with weekly subcutaneous semaglutide 2.4 mg

Several metabolic intermediates, such as long-chain acylcarnitines can cause oxidative stress at high levels and high levels of ROS can then cause damage to cells and tissues, leading to a further decline in performance

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Implement the full prevention protocol described above