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This loss of elasticity may result in hanging or sagging skin that can feel uncomfortable or make clothes fit poorly
According to clinical trial data for semaglutide: nausea (up to 44% of patients) and diarrhoea (~30%) are the top complaints , followed by vomiting (~24%), constipation, and general stomach discomfort
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However, local concentration gradients may favor tissues nearest the injection point, at least initially after administration
The subsequent SURMOUNT-5 head-to-head trial comparing tirzepatide directly against semaglutide showed 20.2% versus 13.7% respectively over the same period
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