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The relationship between Candida and hormonal imbalance is bidirectional: oestrogen promotes Candida adherence and proliferation, while Candida produces oestrogen-mimicking compounds (mycoestrogens) and impairs hepatic oestrogen metabolism, worsening oestrogen dominance
The resulting systemic cytokine storm coincides with ROS attacking tight junction proteins in capillary endothelial cells, inducing microcirculatory leakage [412]
Funding This study was supported by The National Key Research and Development Program of China (2021YFA0910100), Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer (JBZX-202006), Medical Science and Technology Project of Zhejiang Province (WKJ-ZJ-2202, WKJ-ZJ-2104), National Natural Science Foundation of China (82074245, 81973634, 81903842), Natural Science Foundation of Zhejiang Province (LR21H280001), Science and Technology Projects of Zhejiang Province (2019C03049), and Program of Zhejiang Provincial TCM Sci-tech Plan (2018ZY006, 2020ZZ005)
22 (6):e13807 107
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