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This may be preferable for research mainly examining barrier mechanisms or when studying conditions where increased permeability is the main pathological feature

Researchers selecting a compound for a specific endpoint should match mechanism to model rather than treating these peptides as interchangeable

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Week 1: Right thigh, upper-outer quadrant Week 2: Left thigh, upper-outer quadrant Week 3: Right thigh, lower-front quadrant Week 4: Left thigh, lower-front quadrant Week 5: Right thigh, upper-front quadrant Week 6: Left thigh, upper-front quadrant Week 7: Right thigh, lower-outer quadrant Week 8: Left thigh, lower-outer quadrant After eight weeks, the cycle restarts

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