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We first used HEK293T cells, which lack endogenous caspase-1, to identify off-target cleavage events against a clean background (Extended Data Fig

H.WangS

This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

Panuszko, A., Szymczak, M., Duewska, J., Godlewska, J., Kuffel, A., & Brudziak, P