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Sections (5 mm) were stained with Safranin-O/Fast Green and hematoxylin and eosin
By inhibiting sodium resorption, the SGLT2 inhibitor facilitates sodium delivery to the macula densa in the distal tubule, and subsequent tubuloglomerular feedback leads to afferent arteriolar vasoconstriction
Having the math sorted before starting the taper prevents logistical complications that might otherwise derail the gradual reduction plan
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