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The reduction of cardiovascular disease does not decrease medical claims to the point where it is more financially beneficial to include the GLP-1s on the drug formularies because the claims resulting from the medication alone are higher than the claims related to cardiovascular treatments

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Within this framework, we critically examine representative nanotherapeutic strategies across pharmacokinetic and biodistribution-oriented design, vascular and stromal normalization, tumor microenvironment-responsive activation, immune priming and intratumoral reprogramming, and clinically relevant theranostic approaches