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This dose-response ceiling is a central pharmacological fact, not a minor caveat
U73122, ryanodine, and W-7 hydrochloride were from Tocris Bioscience (Ellisville, USA)
Rare side effects may include minor skin rashes or stomach upset
HE and immunochemistry staining Aortic tissues including aortic roots and ascending aorta were collected for preparation of 7 m thick sections
No systematic data exist regarding developmental safety, effects on linear growth and pubertal progression, or long-term cardiometabolic consequences in this population
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