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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys
B.ChisholmD
The Lancet, 402(10401), 529-544.
Focusing on the change in fat mass, however, the patient had actually achieved a reduction of 7.0% ( Supplementary Figure 1 )
Limitations: Diagnostic codes specifically for NAION were lacking
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