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Stockwell et al., 2020)

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Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

Serum response factor regulates bone formation via IGF-1 and Runx2 signals [PMID: 22434656] Laboratory literature summary: Serum response factor regulates bone formation via IGF-1 and Runx2 signals

Lipid peroxidation predominantly creates three harmful byproducts, which are highly cytotoxic, capable of damaging the integrity of cell membranes, increasing membrane permeability, leading to ionic homeostasis imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress, finally leading to cell death (Kwun and Lee, 2023)