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The lethal dose in humans would be approximately 21,000mg for a 70kg person, making the 1-3mg daily doses used in typical protocols extremely safe from a toxicity standpoint
This compound is synthesized inside our cells and plays an important role in maintaining our health
None of that prevents melanocortin receptor pharmacology being a legitimate field, and MC1R signalling in cultured melanocytes is a reasonable thing to study
Vomiting, diarrhea, constipation, reflux-like discomfort, and abdominal cramping can also occur
Madhusoodanan, V., Patel, P., Lima, T
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