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Pharmacologic options historically produced modest weight loss, were limited by tolerability or safety concerns, and rarely demonstrated improvement in hard cardiovascular endpoints

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These approaches address the actual mechanism causing nausea rather than adding unrelated compounds

Rotating Injection Sites Its crucial to rotate tirzepatide injection sites to prevent irritation and ensure optimal absorption

For this purpose, the outcomes of RCTs investigating in PCOS the anthropometric and metabolic changes have been treated separately to better underpin the effects of GLP-1 RA, in particular liraglutide, beyond weight loss