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As the [NADP + ]/[NADPH] ratio, in both the cytosol and the mitochondria, increases with aging the activities of glutathione-disulfide reductase (encoded by the GSR gene

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However, this was not a statistically significant difference, which may be attributed to the relatively small sample size

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The inositide lipid PI4P is specifically enriched at the TGN (Weixel et al., 2005), where its generation drives cholesterol and ceramide transport from ER to Golgi through lipid transfer proteins oxysterol-binding protein (Mesmin et al., 2013) and ceramide transport protein (Simons and Ikonen, 1997