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In reaction to oxidative stress, the protein Keap1 separates from Nrf2 and transfers to the nucleus, where it reacts with antioxidant response elements (AREs), initiating the transcription of genes such as superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and catalase (CAT) (Raslan et al., 2021)
De Carli M, Capezzali E, Tonon S, Frossi B
HSPA2, heat shock protein family A member 2
Tirzepatide is not covered by insurance
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