Elevated calcium levels activate calpains and other calcium-dependent enzymes, which impair mitochondrial function and contribute to neuronal injury
Cell Prolif 2020;53:e12909
It works from inside out to create visible changes
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Alterations in DNA damage repair (DDR) Molecular mechanisms in DDR DDR safeguards genomic stability under genotoxic stress, and its deficiency confers pronounced sensitivity to genotoxic therapies and PARP inhibitors while also driving resistance through repair restoration or pathway bypass
