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A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
While these studies suggest potential benefits, they do not provide the level of evidence needed to confirm safety and efficacy in humans
It is also important to note that self-treating with over-the-counter B12 supplements without a confirmed diagnosis may mask symptoms without addressing the root cause, particularly if the deficiency is due to malabsorption rather than dietary insufficiency
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Higher doses of vitamin B12 may be used to treat a clinically recognised deficiency
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