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Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice

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178,180 The PI3K/Akt signaling pathway, activated by GLP-1, plays a vital role in maintaining pancreatic -cell survival and promoting their proliferation