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Following a review completed in 2024, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) concluded that available evidence did not support a causal link between GLP-1 receptor agonists and suicidal ideation or self-harm, a conclusion also reflected in MHRA communications that year
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Additionally, exendin (a GLP-1R agonist) assays (central and peripheral administration), mRNA central nervous system (CNS) analysis, immunohistochemistry, and fluorescently labeled liraglutide assays were conducted
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