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In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials
This means that it would become more difficult for companies to create copycats, protecting the firm's core GLP-1 products
For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected ( - exposure (Makar et al., 1994)
The ladder is the same for Mounjaro and Zepbound
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