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A small proportion of patients (0.9%) switched to ADM tirzepatide

Semaglutide reduces appetite, which can unintentionally cut protein intake

Editors Note: This article originally appeared in the June 2026 issue of Consumer Reports on Health.

Putting This Into Practice Keep a detailed food and symptom diary noting meal composition, timing, and any reactions Establish a consistent injection schedule and rotation pattern using a calendar or app Prepare smaller portions in advance to avoid overeating when appetite signals change Stay hydrated with clear fluids between meals rather than during eating Monitor blood glucose more frequently if taking other diabetes medications When to Seek Professional Help Severe abdominal pain that persists or worsens over several hours Signs of allergic reaction: rash, itching, swelling of face or throat, difficulty breathing Persistent vomiting preventing fluid intake for more than 24 hours Visual changes or severe headaches Symptoms of hypoglycemia not responding to treatment Decreased urination or signs of dehydration despite adequate fluid intake New lumps in the neck area or voice changes Yellowing of skin or eyes Commonly Asked Questions How long do semaglutide side effects typically last