The DLA Piper analysis of the letter notes that FDA reiterated two principles: (a) AI used for GxP must be validated , and (b) validation documentation should be part of quality records ( [3] )
Such analyses can be performed in epidemiological studies, such as in workers exposed to lead [302, 419], or in in vitro systems which can determine the molecular basis of apoptotic effects [420,421,422,423]
Nature (2018) 556(7699):1225
Additionally, curcumin exhibits significant anti-inflammatory properties by downregulating microglial activation, reducing proinflammatory cytokines, and attenuating TLR4/MyD88/NF-B signaling cascade after TBI (Xie et al., 2014
Incretin-based therapies for type 2 diabetes mellitus