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Signs and symptoms of vitamin B12 deficiency can include fatigue, pale skin, headaches, shortness of breath, fast heartbeat, gastrointestinal issues, mouth inflammation, paresthesias (abnormal sensations), decreased cognitive ability, depression, muscle weakness, imbalance and incoordination, vision problems, and erectile dysfunction
When taken orally, metformin is concentrated in the intestine at levels up to 300 times greater than in the blood, significantly influencing the composition and metabolism of the gut microbiota [16]
MS/MS Data analysis Data were searched against a database compiled from the ReqSeq 2015 database entries for Anopheles gambiae (AgamP4, VectorBase) and Plasmodium berghei (downloaded October 10, 2016) using Proteome Discoverer (version 1.4) and the search engine Mascot (version 2.5.1)
Ren J, Anversa P