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When applied topically, GHK-Cu acts as a skin-restoring compound

Li M, DArcy C, Li X, Zhang T, Joober R, Meng X

Liposomal-glutathione provides maintenance of intracellular glutathione and [PMID: 20535554] Laboratory literature summary: Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells

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What the Data Actually Show | Evidence Level | Sermorelin Alone | GHK-Cu Alone | Sermorelin + GHK-Cu | |---|---|---|---| | Phase III RCT | Yes (pediatric GHD) | No | No | | Phase II RCT (adults) | Yes (Vittone 1997) | One skin-aging trial | No | | Animal studies | Multiple | Multiple | None identified | | In vitro mechanistic | Extensive | Extensive | None identified | | Case series / observational | Limited | Limited | Anecdotal only | The FDA-approved indication for sermorelin covers pediatric GH deficiency