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- Patient should be aware about the rare and serious side effect of bisphosphonates & denosumab (#Osteonecrosis_of_the_jaw (ONJ), so the patients should have a thorough dental evaluation and any necessary treatment before beginning the medication and maintain excellent oral hygiene to minimize risk
Landman AB, Spatz ES, Cherlin EJ, Krumholz HM , Bradley EH, Curry LA
Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years
Male LivPGC-1 mice 15 and wild type (WT) controls in FVBN background were used for study the effect of PGC-1 overexpression
Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity
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