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Pycnogenol s anti-inflammatory ( 2.6 Eye health Owing to its effects on microcirculation, inflammation and oxidation, Pycnogenol was found to have positive effects on eye health ( Pycnogenol showed effects to stop further progression of retinopathy and ameliorate the eyesight of diabetics by stabilizing and sealing leaky capillaries of the retina, stopping further outflow of blood ( In an RDP study, Pycnogenol was shown to reduce capillary leaking in the eyes ( supplementation for two months, the ophthalmoscopy score significantly improved by 9% in the left eyes and by 17% in the right eyes compared to baseline, whereas there was no change observed in the placebo group

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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Subcutaneous Protocol (4 mL = 12.5 mg/mL) Frequency: Inject once or twice daily subcutaneously

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Causal association between kynurenine and depression investigated using two-sample Mendelian randomization