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During the early weeks of treatment, when doses are gradually increased to minimise gastrointestinal side effects, appetite suppression may not yet be fully established
The STEP 1 trial (Wilding et al., NEJM 2021) demonstrated an average 14.9% body weight reduction with semaglutide 2.4mg weekly over 68 weeks, compared to 2.4% with placebo a magnitude of effect that no prior anti-obesity medication had achieved
Frequently Asked Questions Glossary References Sikiric P, et al
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This is particularly relevant because many individuals will regain weight after stopping treatment due to high costs, side effects, or loss of insurance coverage
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