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To overcome this limitation, synthetic GLP-1 analogues like semaglutide, Wegovy, Ozempic, Rybelsus, Retatrutide, and Tirzepatide have been developed
They also help separate product selection from medication dosing, which should come only from a licensed health care source
These peptides should be viewed as adjunctive therapies, complementing lifestyle modifications such as dietary changes, increased physical activity, and behavioral counseling
The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors
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