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Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

This multi-layered cytokine interaction network provides a theoretical basis for combined therapeutic strategies targeting the TME

In DM, an imbalance in the prooxidant/antioxidant equilibrium can result in damage to cellular macromolecules, leading to modifications in DNA and protein, as well as lipid peroxidation [307,308,309]

Inflammatory Bowel Disease Models Research using animal models of IBD (both Crohn's-like and ulcerative colitis-like conditions) has shown BPC-157 [12]: Reduces intestinal inflammation Accelerates mucosal healing Preserves intestinal barrier function Decreases inflammatory cytokine production Prevents fistula formation in some models Intestinal Anastomosis Healing Surgical studies demonstrated that BPC-157 significantly improves the healing of intestinal anastomoses (surgical connections), potentially reducing complications like leakage and stricture formation [13]

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