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Frequently Asked Questions Glossary of Terms References The Lancet

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obesity rate for the past four decades

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases