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For instance, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs are used as an effective first-line therapy

They slow gastric emptying , prolonging the feeling of fullness after meals, and act on appetite centres in the brain to reduce hunger signals

It also increases brain glucose metabolism, providing energy-starved neurons with the fuel they need to process information efficiently

Growth/differentiation factor-15 (GDF-15) Another potential therapeutic pathway for obesity pharmacotherapies is through the stress-induced cytokine GDF-15, which is expressed in multiple cell types including cardiomyocytes, adipocytes and macrophages [98]

Continue tracking water intake if dehydration is a persistent issue