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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

Early changes in vitamin B12 uptake and biomarker status following Roux-en-Y gastric bypass and sleeve gastrectomy

Participants receiving 1 mg per day of AOD 9604 lost approximately 2.6 kg compared to 0.8 kg in the placebo group

Athletes and individuals who exercise daily may have low B12 levels, due to the increased metabolism