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However, results are mixed, but the potential is encouraging

The expression level appeared to be higher in mature leaves than in immature leaves, suggesting its growth-stage specific expression (Park et al., 2004)

What they did: Two parallel series of experiments

Preclinical and clinical studies demonstrate that co-administration of these peptides achieves superior reductions in bodyweight, appetite, and fasting glucose than either agent aloneachieving up to a 17% reduction in bodyweight in non-diabetic individuals and a 15.6% reduction in patients with type 2 diabetes over 2032 weeks

10.1186/s12974-021-02204-0 25 GeronziU.LottiF.GrossoS