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Extra interventions such as stone fragmentation (lithotripsy), balloon dilation of the opening of the common bile duct into the small intestine, or propping open (stenting) the common bile duct may be required along with ERCP if the gallstone is large, impacted, or trapped in front of an obstruction (Molvar 2016
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The substantial impact of LASSS pre-treatment was more pronouncedly demonstrated by an alternative experiment using the disulfide lipoic acid (LA, containing two sulfur atoms connected by a disulfide bond)
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