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Development was terminated, and no pharmaceutical company has pursued AOD 9604 through Phase 3 trials since
Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients
Plus, you may find it harder to sleep at night, which makes your daytime stamina decrease even further
Excess B 12 beyond the blood's binding capacity is typically excreted in urine
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