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To summarise some of the key findings, FMS features: Defective central pain processing characterised by enhanced pronociception and reduced antinociceptive mediators Glutamate excitotoxicity in the central nervous system Neuroinflammation initiated by microglial cells A subset of patients display signs of small fibre neuropathy likely involving hyperexcitability of neurons in the dorsal root ganglia Mitochondrial dysfunction in skin, muscle and white blood cells Structural mitochondrial abnormalities Elevated tissue concentrations of lactate and pyruvate Elevated systemic inflammatory markers Elevated markers of oxidative stress with depleted endogenous antioxidant systems So now that we have rough idea of how the system malfunctions in FMS, we can begin digging deeper into the ways in which thiamine can help to address the abnormalities listed above
However, the potential effects of this supplementation on sperm and testicular oxidative DNA damage were not investigated [50]
SLC7A11 is a key component of the cystine/glutamate antiporter system Xc, which imports cystine for GSH biosynthesis
Jiang, B
Composition: - 10 Vials of Tationil 600mg Glutathione
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