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NSUN5 methylates FTH1/FTL mRNA via m 5 C modification by targeting the 5UTR/3UTR, inducing the degradation of FTH1/FTL mRNA, and leading to decreased iron storage levels and the accumulation of free ferrous ions, causing ferroptosis [42]
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This leads to thinning of the fibrous cap of the plaque and increases the risk of plaque rupture
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In fact, the FDA and medical professionals have cautioned that SARMs, being unregulated, have been associated with some of the same risks as steroids when misused , including potential impacts on the heart and liver
